This online article, written in Portuguese, summarizes a research review conducted to determine whether tricyclic antidepressants (TCAs) can be used to treat autism symptoms, as well as challenging behaviors and co-occurring mental health conditions in autism.

The review found three studies using two TCAs (tianeptine and clomipramine) with people on the autism spectrum. Evidence of positive impacts was limited and sometimes contradictory, and side effects were reported. The article concludes that more research is required before TCAs can be recommended for use with people on the autism spectrum.

Cochrane is a “global independent network of researchers, professionals, patients, carers, and people interested in health.” [Website] The network reviews evidence about health treatments.